The Animal Immunophysiology Laboratory at Changwon National University, located on the 8th floor of the Bio Research Building, has been operating since March 2020. The laboratory focuses on studying immune responses and related diseases based on animal physiology. Additionally, our research covers a broad range of studies utilizing both mouse models and human samples. For more detailed information, please refer to our recent publications.
Our laboratory is conducting a variety of experiments involving extracellular vesicles (EVs). EVs are isolated by collecting bronchoalveolar lavage fluid (BALF) from mice and separating it into apoptotic bodies (Ab), microvesicles (MV), and exosomes through differential centrifugation, depending on the experimental purpose. We primarily utilize equipment such as Nanoparticle Tracking Analysis (NTA), Scanning Electron Microscopy (SEM), and Flow Cytometry to confirm the successful isolation of EVs. These vesicles are further analyzed through techniques such as qPCR and Western blotting. Our ultimate goal is to identify biomarkers and develop therapeutic strategies using EVs.
The respiratory system is involved in gas exchange between the atmosphere and the body. It also has roles in sound production, smell, immunity, and other functions. However, respiratory diseases and conditions can greatly impact an individual’s quality of life and overall health. Thus, in our laboratory, we’re conducting research to treat various diseases in the filed of physiology of respiratory system. Especially, we focus on the drug delivery capabilities of nanoparticles called exosomes.
Our laboratory is currently conducting research on aging-related diseases, with a focus on developing a mass delivery system and identifying biomarkers for the diagnosis and treatment of these diseases. Specifically, we are creating a murine model of lung disease to facilitate our investigations. The ultimate goal of the ongoing project is to alleviate and treat lung diseases caused by aging through these experiments.
STAR Protoc. 2024 Aug 1;5(3):103183.
J Hazard Mater. 2023 Mar 5:445:130466.
Exp Mol Med. 2020 Jun;52(6):887-895
J Exp Med. 2019 Sep 2;216(9):2202-2220
J Control Release. 2019 Jan 28:294:43-52.